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Research
Cholesteryl ester transfer protein gene polymorphisms increase the risk of fatty liver in females independent of adiposityEnvironmental factors including excessive caloric intake lead to disordered lipid metabolism and fatty liver disease.
Research
Effectiveness, Acceptability, and Feasibility of Digital Health Interventions for LGBTIQ+ Young People: Systematic ReviewYoung people (aged 12-25 years) with diverse sexuality, gender, or bodily characteristics, such as those who identify as lesbian, gay, bisexual, transgender, intersex, or queer (LGBTIQ+), are at substantially greater risk of a range of mental, physical, and sexual health difficulties compared with their peers. Digital health interventions have been identified as a potential way to reduce these health disparities.
Research
Borderline Personality Disorder and Peers: A Scoping Review of Friendship, Victimization and Aggression StudiesBorderline personality disorder (BPD) is characterized by instability in interpersonal relationships. To date no reviews have scoped the extant research on peer relationship functioning for young people diagnosed with BPD or showing borderline personality features. The current review provides this scoping of studies on all facets of peer relationships, including friendship quality, peer victimization and bullying and peer aggression, and relevant studies of social–cognitive processes with relevance to peer relationships. From 282 studies identified up to August 2019, 39 studies were included for review.
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Meta-analysis of the neural correlates of vigilant attention in children and adolescentsVigilant Attention (VA), defined as the ability to maintain attention to cognitively unchallenging activities over a prolonged period of time, is critical to support higher cognitive functions and many behaviours in our everyday life. Evidence has shown that VA rapidly improves throughout childhood and adolescence until young adulthood and tends to decline in older adulthood.
Research
Lurasidone for Adolescents With Complex Mental Disorders: A Case SeriesLurasidone is a new second generation (atypical) antipsychotic agent with unique receptor affinity and side-effect profiles, but limited literature is available on its use in adolescent populations. Contrasting with research treatment trials which typically recruit patients by stringent selection criteria, this case series examined the effects and tolerability of using lurasidone in adolescents within real-life clinical settings in treating complex cases who had not responded to other therapy options. We conducted a retrospective case-note audit of 6 adolescents aged 14 to 17 years old attending community child and adolescent mental health services (CAMHS) who were prescribed lurasidone.
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Risk of conduct and oppositional defiant disorder symptoms in offspring of parents with mental health problems: Findings from the Raine StudyEpidemiological data indicate that paternal and maternal mental health difficulties are predictors of conduct disorder (CD) and oppositional defiant disorder (ODD) in offspring. We tested the association between maternal anxiety and depressive symptoms and paternal emotional problems with CD and ODD symptoms in adolescent offspring aged 17.
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Evaluation of a public education campaign to support parents to reduce adolescent alcohol useThe Parents, Young People and Alcohol campaign achieved high awareness and positively influenced parental outcomes
Focus Area
Early EnvironmentThe Early Environment research theme consists of four programs: Immunobiology and Immunotherapeutic, Early Life and Life Course Health, Infection and Vaccines, and End RHD.
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Poverty, Parental Mental Health and Child/Adolescent Mental Disorders: Findings from a National Australian SurveyThe purpose of this study is to examine the association between poverty and child mental disorders
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Trends in alcohol-related injury admissions in adolescents in Western Australia and England: Population-based cohort studyMore needs to be done to address alcohol-related harm, and on-going monitoring is required to assess the effectiveness of strategies.
Research
Risk perception and risk-taking behaviour during adolescence: The influence of personality and genderThis study investigated the influence of personality characteristics and gender on adolescents' perception of risk and their risk-taking behaviour.
News & Events
Meet END RHD CRE Researcher Dr Simone ReynoldsLearn more about the background and motivations of END RHD CRE Research Fellow Simone Reynolds.
Research
Heritable and environmental determinants of hospitalisation for common childhood illnessesWe will leverage the unique Western Australian data linkage resources to undertake the definitive twin and sibling study of infection-related hospitalisation
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Bronchial brushings for investigating airway inflammation and remodellingAsthma is the commonest medical cause for hospital admission for children in Australia, affects more than 300 million people worldwide, and is incurable...
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Does Exposure to Asbestos Cause Ovarian Cancer? A Systematic Literature Review and Meta-analysisThe asbestos and ovarian cancer relationship is not well understood because of small numbers of women exposed to asbestos, small numbers of cases...
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Opportunities and challenges of the pulmonary route for vaccinationThe respiratory tract is an attractive target for the delivery of vaccine antigens.
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Preterm infants have deficient monocyte and lymphocyte cytokine responses to group B streptococcusGroup B streptococcus (GBS) is an important cause of early- and late-onset sepsis in the newborn. Preterm infants have markedly increased susceptibility...
Research
Bone mineral content and density in Rett syndrome and their contributing factorsThis study used densitometry to investigate the areal bone mineral density (aBMD) and bone mineral content (BMC) in an Australian Rett syndrome cohort...