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Parental smoking, maternal alcohol consumption during pregnancy and the risk of neuroblastoma in children. A pooled analysis of the ESCALE and ESTELLE French studiesOur findings provide some evidence of an association between maternal smoking during pregnancy and Neuroblastoma
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An update on allergy and anaphylaxis in pediatric anesthesiaWe review the pathophysiology of hypersensitivity reactions and the implications for anesthesia of food allergy, atopy, and family history of allergy in children
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The reproduction of educational inequalities – do parenting and child behavioural problems matter?Parenting styles and child behavioural problems may be potential pathways that underpin the influence of parental SES on children’s school achievement
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Optimisation of multiplex immunofluorescence for a non-spectral fluorescence scanning systemHere we present two 5-colour immunofluorescence panels designed for T cell characterisation in human colorectal tissue
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Healthy population ageing depends on investment in early childhood learning and developmentInterventions in the early years provide a sustainable solution by generating long-term labour productivity and social welfare benefits
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Severity Assessment in CDKL5 Deficiency DisorderA severity assessment was rapidly developed with input from multiple stakeholders. Refinement through ongoing validation is required for future clinical trials.
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New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironmentWe provide evidence that targeting leukemia-induced bone loss is a therapeutic strategy for pre-B ALL
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ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testingAssessment of airway hyperresponsiveness are valuable tools to understand and to monitor airway function and to characterise the underlying asthma phenotype to guide therapy
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C1 CAGE detects transcription start sites and enhancer activity at single-cell resolution.We introduce C1 CAGE, a method for the detection of transcript 5'-ends with an original sample multiplexing strategy in the C1TM microfluidic system
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Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosisOur data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target