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COPD-related modification to the airway epithelium permits intracellular residence of nontypeable haemophilus influenzaeOur findings indicate that COPD, cigarette smoke and macrolide antibiotics potentiate the susceptibility to persistent intracellular NTHi
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Durvalumab with first-line chemotherapy in previously untreated malignant pleural mesothelioma (DREAM): a multicentre, single-arm, phase 2 trial with a safety run-inThere is a strong unmet need to improve systemic therapy in mesothelioma. Chemotherapy with cisplatin and pemetrexed improves survival in malignant pleural mesothelioma, and immune checkpoint inhibitors are an emerging treatment in this disease. We aimed to evaluate the activity of durvalumab, an anti-PD-L1 antibody, given during and after first-line chemotherapy with cisplatin and pemetrexed in patients with advanced malignant pleural mesothelioma.
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A longitudinal study of natural antibody development to pneumococcal surface protein A families 1 and 2 in Papua New Guinean Highland children: a cohort studyPneumococcal surface protein A is immunogenic and natural anti-PspA immune responses are acquired through exposure and develop with age
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How can clinical ethics guide the management of comorbidities in the child with Rett syndrome?This paper reviews the disorder Rett syndrome and evidence for the management of scoliosis and poor growth within a clinical ethics framework
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A systematic approach to multiple breath nitrogen washout test qualityThe application of the systematic review improved inter-observer agreement but did not affect reported multiple breath washout outcomes
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Effect of amino acid polymorphisms of house dust mite Der p 2 variants on allergic sensitizationMeasures of allergic sensitization and therapeutic strategies could be optimized with knowledge of Der p 2 variants
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Respiratory syncytial virus is present in the neonatal intensive care unitThe results suggest that though the risk for RSV in the NICU remains low, personnel clothing are contaminated with RSV-RNA and may have a role in transmission
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Outcome measures for artificial pancreas clinical trials: A consensus reportResearch on and commercial development of the artificial pancreas (AP) continue to progress rapidly, and the AP promises to become a part of clinical care.
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Continuous active surveillance of adverse events following immunisation using SMS technologyAutomated SMS-based reporting can facilitate sustainable, real-time, monitoring of adverse reactions and early identification of potential vaccine safety issues
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The Role of Preschool Quality in Promoting Child Development: Evidence from Rural IndonesiaThis paper reports on the quality of early childhood education in rural Indonesia