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Transmission potential of Streptococcus pyogenes during a controlled human infection trial of pharyngitisControlled human infection (CHI) models can provide insights into transmission of pathogens such as Streptococcus pyogenes (Strep A). As part of the Controlled Human Infection with Penicillin for Streptococcus pyogenes (CHIPS) trial, we explored the potential for transmission among participants deliberately infected with the Strep A emm75 strain.
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Host-dependent resistance of Group A Streptococcus to sulfamethoxazole mediated by a horizontally-acquired reduced folate transporterDescribed antimicrobial resistance mechanisms enable bacteria to avoid the direct effects of antibiotics and can be monitored by in vitro susceptibility testing and genetic methods. Here we describe a mechanism of sulfamethoxazole resistance that requires a host metabolite for activity.
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Antimicrobial stewardship in remote primary healthcare across northern AustraliaThe high burden of infectious disease and associated antimicrobial use likely contribute to the emergence of antimicrobial resistance in remote Australian Aboriginal communities. We aimed to develop and apply context-specific tools to audit antimicrobial use in the remote primary healthcare setting.
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Aboriginal Urban Healthy Skin studyAsha Brad Glenn Jonathan Marianne Tim Bowen Farrant Pearson Carapetis AM Mullane Barnett BA MBBS DCH FRACP PhD GAICD FAHMS OAM BSc (Hons), PhD BA (
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Acute Rheumatic Fever Diagnosis Collaborative Network (ARC)ARC is a global network of collaborators committed to reducing the burden of RHD in our lifetime.
Kaal is a proud Noongar boy, he loves playing football, but this season Kaal is about to tackle a new and unexpected challenge… eczema.
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Molecular Detection of Scabies by PCR Using a Next Generation Sequencing (NGS) ApproachIn recent years, the interest in molecular diagnostic methods for the detection of many pathogens has grown substantially.
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Moorditj Marp (Strong Skin) Evaluation and development of culturally relevant healthy skin storybooksCo-designed and in collaboration with community members, the impacts of this project will directly benefit families by building awareness, empowering decision-making, and improving confidence around the recognition and management of skin conditions for Aboriginal children.
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SNAP-Chat: the Staphylococcus aureus Network Adaptive Platform Trial (SNAP) - ChatDr Anita Asha Campbell Bowen MBBS, DCH, PG DipPID, FRACP, PhD BA MBBS DCH FRACP PhD GAICD FAHMS OAM Infectious Diseases Physician; Raine Clinician
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A Survey of Infectious Diseases and Microbiology Clinicians in Australia and New Zealand About the Management of Staphylococcus aureus BacteremiaSignificant variation in practice, particularly for patients with a severe disease phenotype and antibiotic-resistant profile