Search
Research
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4Previous genome-wide association studies revealed multiple common variants involved in eczema but the role of rare variants remains to be elucidated. Here, we investigate the role of rare variants in eczema susceptibility. We meta-analyze 21 study populations including 20,016 eczema cases and 380,433 controls. Rare variants are imputed with high accuracy using large population-based reference panels.
Research
After asthma: Redefining airways diseasesIdentify entrenched areas of asthma management and treatment in which progress has stalled and to challenge current principles
Research
Trajectories of childhood immune development and respiratory health relevant to asthma and allergyOur findings demonstrate the utility of unsupervised analysis in elucidating heterogeneity in asthma pathogenesis
Research
Risk factors and prognosis of recurrent wheezing in Chinese young children: A prospective cohort studyWe aimed to investigate the risk factors for different wheezing phenotypes in Chinese young children and to explore the prognosis of recurrent wheezing
Research
Fish oil supplementation in early infancy modulates developing infant immune responsesMaternal fish oil supplementation during pregnancy has been associated with altered infant immune responses and a reduced risk of infant sensitization and...
Research
Prophylactic use of sublingual allergen immunotherapy in high-risk children: A pilot studyThese findings suggest that this modified version of SLIT should be considered for retesting of mucosal-based immunotherapy for atopic asthma prevention.
Research
Viral infections and atopy in asthma pathogenesis: New rationales for asthma prevention and treatmentProspective birth cohort studies tracking asthma initiation and consolidation in community cohorts have identified viral infections occurring against a...
Research
Low maternal serum vitamin D during pregnancy and the risk for postpartum depression symptomsPregnancy is a time of vulnerability for vitamin D insufficiency, and there is an emerging literature associating low levels of 25(OH)-vitamin D with...
Research
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotypePrevious analyses of family data from the Tasmanian Longitudinal Health Study provide evidence that this phenotype has a stronger genetic cause than asthma...
Research
Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predispositionThere is evidence to suggest an association between prenatal maternal stress and the development of asthma or other atopic diseases in offspring.