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An exposome perspective: Early-life events and immune development in a changing world

Here we review the historical origins of exposome research and define a new concept, the metaexposome

Vitamin D over the first decade and susceptibility to childhood allergy and asthma

We aimed to research relationships between 25(OH)D levels from birth to 10 y/o and susceptibility to allergic sensitization, respiratory issues and asthma.

Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children

The present study aimed to clarify the effect of viral and bacterial co-detections on disease severity during paediatric acute respiratory infection (ARI).

Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers

We sought to assess whether the trajectory to asthma begins already at birth and whether epigenetic mechanisms, contribute to asthma inception.

Tracking of Vitamin D status from childhood to early adulthood and its association with peak bone mass

There are moderate associations between vitamin D status measured in prepuberty, adolescence, and early adulthood

Mannitol challenge testing for asthma in a community cohort of young adults

We aimed to quantify the diagnostic utility of mannitol challenge testing for asthma in a community cohort and a symptomatic wheezing subset of this cohort.

Protection against maternal infection-associated fetal growth restriction: Proof-of-concept with a microbial-derived immunomodulator

This study suggests that broad-spectrum protection-of-pregnancy against infection-associated inflammatory stress represents an achievable therapeutic goal

Population-based estimates of the effectiveness of pneumococcal vaccination in Australia

Australia’s Childhood Immunisation Register (ACIR) is one of only a handful of national immunisation registers world-wide.

Identification and characterization of a dendritic cell precursor in parenchymal lung tissue

This is the first study to describe a pulmonary precursor cell for dendritic cells in lung tissue

Severe winter asthma exacerbations can be prevented by omalizumab, but there is no carryover effect.

Recurrent severe asthma exacerbations are associated with decreased lung growth or accelerated loss of long function and add substantially to cost and morbidity