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Research

The Evolving Landscape of e-Cigarettes: A Systematic Review of Recent Evidence

This review focuses on smokers and nonsmokers and evaluates the most recent data regarding the potential health effects of e-cigarettes

Research

Early-life exposure to electronic cigarettes: cause for concern

There are a multitude of ways that, with respect to early-life exposures and health, electronic nicotine delivery systems are a cause for concern

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Transplacental immune modulation with a bacterial-derived agent protects against allergic airway inflammation

These data provide proof of concept supporting the rationale for developing transplacental immune reprogramming approaches for primary disease prevention

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Biodiesel exhaust-induced cytotoxicity and proinflammatory mediator production in human airway epithelial cells

Canola biodiesel exhaust exposure elicits inflammation and reduces viability of human epithelial cell cultures in vitro when compared with ULSD exhaust exposure

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Geogenic PM10 exposure exacerbates responses to influenza infection

This study aimed to determine whether chronic, low-dose exposure to geogenic particulate matter <10μm diameter (PM10) exacerbates viral infections of the...

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In utero cigarette smoke exposure impairs somatic and lung growth in BALB/c mice

The aim of this study was to assess whether in utero tobacco smoke exposure alone affects early-life lung growth and development. Pregnant BALB/c mice...

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Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following influenza A virus infection

Immunological homeostasis in the respiratory tract is thought to require balanced interactions between networks of dendritic cell (DC) subsets in lung...

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Sensitizing and Th2 Adjuvant Activity of Cysteine Protease Allergens

Here, we report on a model that does not use Th2-skewing adjuvants and yet achieves sensitization solely via the nasal mucosa.

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Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeability

HRV-1B infection directly alters human airway epithelial TJ expression leading to increased epithelial permeability potentially via antiviral response of IL-15

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Vitamin D supplementation of initially vitamin D-deficient mice diminishes lung inflammation with limited effects on pulmonary epithelial integrity

In disease settings, vitamin D may be important for maintaining optimal lung epithelial integrity and suppressing inflammation, but less is known of its effects prior to disease onset.