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Research

Immunosuppressive mechanisms of oncofetal reprogramming in the tumor microenvironment: implications in immunotherapy response

Both fetal and tumor tissue microenvironments display immunosuppressive features characterized by the presence of specific immunomodulatory stromal and immune cell populations. Recently, we discovered shared microenvironments between hepatocellular carcinoma and fetal tissues and described this phenomenon as an oncofetal ecosystem.

Research

The non-specific effects of maternal immunization on birth outcomes: The evidence, mechanisms, and the implications

Preterm birth (PTB) and stillbirth remain two of the most important causes of death, morbidity, and disability in childhood. Despite efforts to reduce PTB and stillbirth worldwide, rates of these adverse outcomes remain persistently elevated, independent of income setting. There is an urgent need for more effective interventions to reduce associated neonatal and early childhood morbidity and mortality.

The Raine Study: three decades of life-changing research

Between 1989 and 1991, almost 3,000 WA babies were recruited to the Raine Study - an ambitious research project which would yield a series of paradigm-shifting findings that changed scientific thinking. Three decades on, it has also changed the lives of those taking part.

Horse wisdom making a difference in the Kimberley

The Yawardani Jan-ga Equine-Assisted Learning (EAL) research project, headed by Professor Juli Coffin in WA’s Kimberley region, is steadily growing its capacity to support the social, emotional and spiritual wellbeing of Aboriginal young people through the powerful medium of horses.

Bright Tomorrows app offers families support during COVID-19

A comprehensive app produced by The Kids researchers has offered parents a lifeline as they try to cope with the isolation and disruption caused by coronavirus.

Perseverance pays off for critically ill patients

A legal change fought for by The Kids, consumer advocates, and others within the health sector – and hastened by the COVID-19 crisis – has brought WA into line with the rest of Australia, allowing critically ill or incapacitated patients access to potentially life-saving clinical trials.

Autism guide makes art accessible for all

For children with Austin Spectrum Disorder (ASD), it can be hard to enjoy the simple pleasures of art, but the development of an ASD guide is helping to share the wonders of art with all.

Research

Causal Impact of Physical Activity on Child Health and Development

The relationship between physical activity and child health and development is well-documented, yet the extant literature provides limited causal insight into the amount of physical activity considered optimal for improving any given health or developmental outcome.

Research

Urinary tract infections in children: building a causal model-based decision support tool for diagnosis with domain knowledge and prospective data

Diagnosing urinary tract infections (UTIs) in children in the emergency department (ED) is challenging due to the variable clinical presentations and difficulties in obtaining a urine sample free from contamination.