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CXCR3 is associated with T-cell-induced heart damage in acute rheumatic fever

The pathogenesis of acute rheumatic fever (ARF) is poorly understood, limiting the development of immune-modulating therapies to treat disease and prevent progressive heart damage. Here, participants with definite ARF were compared to other severe acute paediatric conditions and matched healthy controls by profiling circulating immune molecules and cells to inform disease mechanisms and potential druggable pathways.

Perturbation of the T Cell Compartment Underlies Rheumatic Fever Pathogenesis

This prospective cohort study, which recruited participants with definite ARF in Australia and Aotearoa New Zealand, profiled circulating immune molecules and cells to inform disease mechanisms and future druggable pathways.

Rural Cancer Siblings

We want to hear from siblings living outside of Australian cities!

Recruits needed for coeliac and diabetes study

Our researchers want to know if starting a gluten-free diet reduces daily glycaemic variability in children and young people with both type 1 diabetes and newly-diagnosed coeliac disease.

Oral Insulin Trial

To see if giving insulin by mouth (in a capsule) will delay or prevent T1DM in people at increased risk of developing diabetes.

Understanding how you manage hypos

If you, or your child is aged between 2 – 18 years and has type 1 diabetes, we invite you to complete a few questions to help us see how you manage your hypos at home.

Global Scales for Early Development: Piloting the Family Check Up Program

Every year, over 80,000 Western Australian children will have a diagnosed mental health disorder.

Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin

Present a valuable resource for drug discovery and have identified ROM as a promising therapeutic for MLL-rearranged iALL

Increased Body Mass Index during Therapy for Childhood Acute Lymphoblastic Leukemia: A Significant and Underestimated Complication

We undertook a retrospective review of children diagnosed with acute lymphoblastic leukemia (ALL) and treated with modern COG protocols to determine...

Hepatic sinusoidal obstruction syndrome during chemotherapy for childhood medulloblastoma: Report of a case and review of the literature

We report a patient with high-risk anaplastic medulloblastoma who developed severe HSOS during her second cycle of maintenance chemotherapy.