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Co-occurring Neurodevelopmental Conditions in Children: Advocating for Transdiagnostic Approach to AssessmentsApproximately 8% of all children experience developmental and mental health conditions. Similarities in characteristics across neurodevelopmental conditions-such as difficulties in communication and language, social interaction, motor coordination, attention, activity regulation, behavior, mood, and sleep-make it challenging to attribute these characteristics exclusively to specific diagnoses and assessments. The purpose of this study was to identify symptomatic domains across neurodevelopmental conditions in children and to explore dimension reduction for transdiagnostic assessment.
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Characterizing the Nature of Alexithymia in Autistic Adults: Validation of the Perth Alexithymia QuestionnaireAlexithymia—a trait characterized by difficulties in emotion processing—is of high interest in the autism field. However, the lack of validated alexithymia measures for autistic individuals limits progress. This study aimed to address this gap by examining the psychometric properties of the Perth Alexithymia Questionnaire (PAQ) across autistic and non-autistic samples. Using the PAQ, we investigated how alexithymia manifests in autistic individuals and its links with poor mental health outcomes (anxiety).
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Pre-emptive intervention versus treatment as usual for infants showing early behavioural risk signs of autism spectrum disorderA pre-emptive intervention for the autism spectrum disorder prodrome had no immediate treatment effect on early autism spectrum disorder symptoms
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The effect of functioning on Quality of Life Inventory-Disability measured quality of life is not mediated or moderated by parental psychological distressThe measurement of quality of life (QOL) in children with intellectual disability often relies upon proxy report via caregivers. The current study investigated whether caregiver psychological distress mediates or moderates the effects of impairment on their ratings of QOL in children with intellectual disability.
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Genetic counseling as preventive intervention: toward individual specification of transgenerational autism riskAlthough autism spectrum disorders (ASD) are among the most heritable of all neuropsychiatric syndromes, most affected children are born to unaffected parents. Recently, we reported an average increase of 3-5% over general population risk of ASD among offspring of adults who have first-degree relatives with ASD in a large epidemiologic family sample.
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Autism-related dietary preferences mediate autism-gut microbiome associationsThere is increasing interest in the potential contribution of the gut microbiome to autism spectrum disorder (ASD). However, previous studies have been underpowered and have not been designed to address potential confounding factors in a comprehensive way.
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Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorderASD's are complex, pervasive and heterogeneous neurodevelopmental conditions with varying conditions, trajectories, significant male bias and unknown etiology.
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Associations between Handedness and Cerebral Lateralisation for Language: A Comparison of Three Measures in ChildrenIt has been suggested that quantitative measures of differential hand skill or reaching preference may provide more valid measures than traditional...
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Maternal vitamin D levels during pregnancy and offspring eating disorder risk in adolescenceThis is the first study to link low gestational vitamin D to increased eating disorder risk in female offspring of Caucasian mothers.
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A "bottom-up" approach to aetiological research in autism spectrum disordersAutism spectrum disorders (ASD) are currently diagnosed in the presence of impairments in social interaction and communication, and a restricted range of...