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Neutrophils are a type of immune cell that can trigger inflammation and may play a role in the development of MS.

Multiple sclerosis (MS) is an immune-mediated inflammatory disease of the central nervous system that results in demyelination of axons, inefficient signal transmission and reduced muscular mobility. Recent findings suggest that B cells play a significant role in disease development and pathology. To further explore this, B cell profiles in peripheral blood from 28 treatment-naive patients with early MS were assessed using flow cytometry and compared to 17 healthy controls.

The immunological mechanisms that contribute to multiple sclerosis (MS) differ between males and females. Females are 2-3 times more likely to develop MS compared to males, however the reason for this discrepancy is unknown. Once MS is established, there is a more inflammatory yet milder form of disease in females whereas males generally suffer from more severe disease and faster progression, neural degradation, and disability.

Our team aims to better understand how the immune response to immune challenges, such as viral infections can influence the risk of developing asthma or autoimmune disease.

The overarching aim of this project is to understand how plasmacytoid dendritic cells function in children with asthma and how genes and environmental stimuli influence these cells.