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Expression of CYP24A1 and other multiple sclerosis risk genes in peripheral blood indicates response to vitamin D in homeostatic and inflammatory conditionsAlthough genetic and epidemiological evidence indicates vitamin D insufficiency contributes to multiple sclerosis (MS), and serum levels of vitamin D increase on treatment with cholecalciferol, recent metanalyses indicate that this vitamin D form does not ameliorate disease. Genetic variation in genes regulating vitamin D, and regulated by vitamin D, affect MS risk.
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Sun-immune connectionExposure to ultraviolet radiation damages skin cell DNA but skin cancers develop because ultraviolet radiation also affects the immune system
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Immune mechanisms by which topically applied vitamin D acts as a therapeutic agentVitamin D, nutrition, diet, therapeutic agent
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Acute Erythemal Ultraviolet Radiation Causes Systemic Immunosuppression in the AbsenceVitamin D is synthesised by ultraviolet (UV) irradiation of skin and is hypothesized to be a direct mediator.
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Analytical bias in the measurement of plasma 25-hydroxyvitamin D concentrations in infantsTo our knowledge, this is the first study to show that the reported 25(OH)D concentration may be influenced by both age and assay type
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Low-dose UV radiation before running wheel access activates brown adipose tissueWhen combined with physical activity, low-dose UVR may more effectively limit adiposity and modulate metabolic and immune pathways in iBAT
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Tracking of Vitamin D status from childhood to early adulthood and its association with peak bone massThere are moderate associations between vitamin D status measured in prepuberty, adolescence, and early adulthood
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House dust mite induced lung inflammation does not alter circulating vitamin D levelsWe hypothesized that allergic inflammation decreases the level of circulating 25(OH)D and tested this using a mice model of house dust mite (HDM) induced...
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Sun exposure and vitamin D status as northeast asian migrants become acculturated to life in AustraliaTargeted public health approaches are required to manage the high prevalence of vitamin D deficiency in migrants retaining a traditional lifestyle
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Seasonal variation of relapse rate in multiple sclerosis is latitude dependentWe demonstrate a latitude-dependent relationship between seasonal UVR trough and relapse onset probability peak independent of location-specific UVR levels