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Research

Going back to the future with Guthrie-powered epigenome-wide association studies

Epigenome-wide association studies (EWAS) can be used to investigate links between early life environment, epigenetics and disease...

Research

Re-evaluation of link between interpregnancy interval and adverse birth outcomes: Retrospective cohort study matching two intervals per mother

This study questions the causal effect of short interpregnancy intervals on adverse birth outcomes and points to the possibility of unmeasured or...

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Autism spectrum disorder in children born preterm: Role of exposure to perinatal inflammation

This review aims to summarise and evaluate the potential mechanisms and evidence for the role of prenatal infection on the central nervous system, and how it...

Research

A Genome-Wide Search for Type 2 Diabetes Susceptibility Genes in an Extended Arab Family

We performed a discovery GWAS in an extended UAE family (N = 178; 66 diabetic; 112 healthy) genotyped on the Illumina Human 660 Quad Beadchip, with...

Research

Effects of adopting the new global lung function initiative 2012 reference equations on the interpretation of spirometry

The aim of this study was to document the likely interpretative effects of changing from commonly used current spirometry reference equations to the GLI2012...

Research

Novel end points for clinical trials in young children with cystic fibrosis

Cystic fibrosis (CF) lung disease commences early in the disease progression and is the most common cause of mortality.

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Genetic and epigenetic susceptibility to early life infection

To date there have been relatively few studies on genetic determinants of susceptibility to neonatal infection and many of these have methodological...

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The Childhood Leukemia International Consortium

The Childhood Leukemia International Consortium (CLIC) was established in 2007 to promote investigations of rarer exposures, gene-environment interactions...

Research

Effect of private insurance incentive policy reforms on trends in coronary revascularisation procedures

There is currently a lack of evidence on the effect of the policy reforms on access to cardiovascular interventions in public and private hospitals in...

Research

Online healthy lifestyle support in the perinatal period: What do women want and do they use it?

This paper presents a project designed to provide online information to promote healthy lifestyles in the perinatal period.