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Neurocognitive Outcomes in Young Adults With Early-Onset Type 1 DiabetesThe aim of this study was to reexamine the neurocognitive function of a cohort of young adults with early-onset type 1 diabetes and compare their cognitive...
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Lower cardiorespiratory fitness in children with Type 1 diabetesThe present study aimed to compare cardiorespiratory fitness levels in children with and without Type 1 diabetes.
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Type 1 diabetes in children - emergency managementFifteen to sixty-seven percent of patients with new onset type 1 diabetes mellitus (T1DM) present in diabetic ketoacidosis (DKA), of which approximately...
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Perinatal risk factors for childhood Type 1 diabetes in Western Australia - a population-based study (1980-2002)To investigate perinatal risk factors for childhood Type 1 diabetes in Western Australia, using a complete population-based cohort.
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A microRNA-based dynamic risk score for type 1 diabetesIdentifying individuals at high risk of type 1 diabetes (T1D) is crucial as disease-delaying medications are available. Here we report a microRNA (miRNA)-based dynamic (responsive to the environment) risk score developed using multicenter, multiethnic and multicountry ('multicontext') cohorts for T1D risk stratification. Discovery (wet and dry lab) analysis identified 50 miRNAs associated with functional β cell loss, which is a hallmark of T1D.
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Protocol for the Australian Type 1 Diabetes National Screening Pilot: Assessing the feasibility and acceptability of three general population screening models in childrenOne third of Australian children diagnosed with type 1 diabetes present with life-threatening diabetic ketoacidosis (DKA) at diagnosis. Screening for early-stage, presymptomatic type 1 diabetes, with ongoing follow-up, can substantially reduce this risk (<5% risk). Several screening models are being trialled internationally, without consensus on the optimal approach. This pilot study aims to assess three models for a routine, population-wide screening programme in Australia.
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Study Protocol for a Stepped-Wedge Cluster (Nested) Randomized Controlled Trial of Antenatal Colostrum Expression (ACE) Instruction in First-Time Mothers: The ACE StudyAlthough many mothers initiate breastfeeding, supplementation with human-milk substitutes (formula) during the birth hospitalization is common and has been associated with early breastfeeding cessation. Colostrum hand expressed in the last few weeks before birth, known as antenatal colostrum expression (ACE), can be used instead of human-milk substitutes. However, evidence is lacking on the efficacy of ACE on breastfeeding outcomes and in non-diabetic mothers.
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A Database of the Complications of Obesity in ChildrenThe Obesity Database records the characteristics and medical complications of children with obesity who present to treatment at Princess Margaret Hospital
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Oral Insulin TrialTo see if giving insulin by mouth (in a capsule) will delay or prevent T1DM in people at increased risk of developing diabetes.
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Feasibility of 24-hour hybrid closed loop insulin delivery in free living conditionsThe aim of this study is to see if the Medtronic hybrid closed loop system, a portable artificial pancreas is feasibly to use in the home.