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The suboptimal sensitivity and specificity of available diagnostic methods for scabies hampers clinical management, trials of new therapies and epidemiologic studies. Additionally, parasitologic diagnosis by microscopic examination of skin scrapings requires sample collection with a sharp scalpel blade, causing discomfort to patients and difficulty in children. Polymerase chain reaction (PCR)-based diagnostic assays, combined with non-invasive sampling methods, represent an attractive approach.
These data highlight the importance of recognising Sporotrichosis in children outside an outbreak setting
The Australian National Healthy Skin Guideline summarises evidence-based treatment of impetigo, scabies and fungal infections in high burden settings
We write this perspective to raise awareness of antimicrobial resistance as an issue in Indigenous primary health care
Health care-associated bacteraemia has a significant impact on child health, exceeding the number of community-acquired bacteraemia at our hospital
Skin infections are an under-appreciated and dominant reason for presentation to primary healthcare centres in these indigenous communities
Implementation of molecular testing could improve antibiotic use in this high-burden setting
A summary of the literature regarding the use of adjunctive protein synthesis inhibitors for toxin suppression in the setting of S. aureus infections is presented
There is a wide spectrum of disease severity in paediatric Staphylococcus aureus bacteraemia
Citation: MacDonald B, Burmaz M, Baker S, et al. TrialR: critical enablers and the need for reusable Rare Disease Clinical Trial infrastructure in