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The effect of the social and physical environment on children's independent mobility to neighborhood destinationsRelationships between context-specific measures of the physical and social environment and children's independent mobility to neighborhood destination types...
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Telomerase reverse transcriptase regulates microRNAs.This study reports that telomerase reverse transcriptase extensively affects the expression levels of mature microRNAs.
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An evaluation of a data linkage training workshop for research ethics committeesIn Australia research projects proposing the use of linked data require approval by a Human Research Ethics Committee (HREC).
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Analysis of tandem E-box motifs within human Complement receptor 2 (CR2/CD21) promoter reveals cell specific roles for RP58...Complement receptor 2 (CR2/CD21) plays an important role in the generation of normal B cell immune responses.
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Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinationsCancer immunotherapy has shown impressive results, but most patients do not respond.
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'If I Wanted to Have More Opportunities and Go to a Better School, I Just Had to Get Used to It’The experiences of 32 male Aboriginal students from regional and remote towns and communities while they attended a metropolitan boarding school...
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Safety, tolerability, and effect of a single aural dose of Dornase alfa at the time of ventilation tube surgery for otitis media: A Phase 1b double randomized control trialOne third of children require repeat ventilation tube insertion (VTI) for otitis media. Disease recurrence is associated with persistent middle ear bacterial biofilms. With demonstration that Dornase alfa (a DNase) disrupts middle ear effusion biofilms ex vivo, we identified potential for this as an anti-biofilm therapy to prevent repeat VTI. First, safety and tolerability needed to be measured.
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Trends in treatment-seeking for fever in children under five years old in 151 countries from 1990 to 2020Access to medical treatment for fever is essential to prevent morbidity and mortality in individuals and to prevent transmission of communicable febrile illness in communities. Quantification of the rates at which treatment is accessed is critical for health system planning and a prerequisite for disease burden estimates.
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A surgically optimized intraoperative poly(I:C)-releasing hydrogel prevents cancer recurrenceRecurrences frequently occur following surgical removal of primary tumors. In many cancers, adjuvant therapies have limited efficacy. Surgery provides access to the tumor microenvironment, creating an opportunity for local therapy, in particular immunotherapy, which can induce local and systemic anti-cancer effects.
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The ORIGINS Project Biobank: A Collaborative Bio Resource for Investigating the Developmental Origins of Health and DiseaseEarly onset Non-Communicable Diseases (NCDs), including obesity, allergies, and mental ill-health in childhood, present a serious and increasing threat to lifelong health and longevity. The ORIGINS Project (ORIGINS) addresses the urgent need for multidisciplinary efforts to understand the detrimental multisystem impacts of modern environments using well-curated large-scale longitudinal biological sample collections.