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Investigating the role of Neutrophils in Multiple Sclerosis

Neutrophils are a type of immune cell that can trigger inflammation and may play a role in the development of MS.

Investigators

Dr. Stephanie Trend, Dr. Luke Garratt, Prof. Anne Bruestle, Prof. Allan Kermode, Prof. Prue Hart, Dr. Jonatan Leffler

Project description

Neutrophils are a type of immune cell that can trigger inflammation and may play a role in the development of MS. In addition, our research team has recently shown that B cells, an important immune cell that is targeted by current drugs for MS, might be activated by proteins produced by neutrophils. Therefore, we are investigating whether there is any link between the two cell types in people with early MS. If neutrophils are found to be important in triggering B cells in MS, then new drugs might be developed to target them in future. 

Funders

MS Australia

External collaborators

A/Prof. Anne Bruestle, Prof. Allan Kermode