A differentiated nasal epithelial cell model derived from children with acute wheeze and asthma

The airway epithelium is the primary structural and functional airway barrier and orchestrates innate immunity. Some children may have underlying epithelial vulnerabilities that contribute to the pathogenesis of acute wheeze and asthma.

Citation:
Watkinson RL, Montgomery ST, Berry L, Gwatimba A, Coleman LA, Khoo SK, Troy N, Prastanti F, Borland M, Le Souf PN, Iosifidis T, Looi K, Laing IA, Kicic A. A differentiated nasal epithelial cell model derived from children with acute wheeze and asthma. Ann Allergy Asthma Immunol. 2025

Keywords:
Airway; epithelium; innate immunity; wheeze; asthma

Abstract:
The airway epithelium is the primary structural and functional airway barrier and orchestrates innate immunity. Some children may have underlying epithelial vulnerabilities that contribute to the pathogenesis of acute wheeze and asthma.