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A Longitudinal Study of Children's Hippocampal Development: Investigating Maternal Physical Activity, Depression, and Education

The developing hippocampus is particularly sensitive to early environmental influences, including during pregnancy. This longitudinal neuroimaging study examined associations between prenatal maternal physical activity and depression, maternal education, and hippocampal development from early childhood to early adolescence.

Citation:
Aghamohammadi-Sereshki A, Reynolds JE, Singh M, Roeske J, et al. A Longitudinal Study of Children's Hippocampal Development: Investigating Maternal Physical Activity, Depression, and Education. Dev Neurobiol. 2026;86(2). 

Keywords:
APrON study; depression; diffusion tensor imaging; hippocampal development; longitudinal study; magnetic resonance imaging; physical activity

Abstract:
The developing hippocampus is particularly sensitive to early environmental influences, including during pregnancy. This longitudinal neuroimaging study examined associations between prenatal maternal physical activity and depression, maternal education, and hippocampal development from early childhood to early adolescence.