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Innate epithelial and functional differences in airway epithelium of children with acute wheeze

Early childhood wheeze is a major risk factor for asthma. However, not all children who wheeze will develop the disease. The airway epithelium has been shown to be involved in asthma pathogenesis. Despite this, the airway epithelium of children with acute wheeze remains poorly characterized.

Citation:
Looi K, Iosifidis T, Harrison S, Stick SM, LeSouef P, Laing IA, Kicic A. Innate epithelial and functional differences in airway epithelium of children with acute wheeze. Frontiers in Cell and Developmental Biology. 2025;13.

Keywords:
Acute wheeze; airway epithelium; barrier integrity; cell culture; conditional reprogramming

Abstract:
Early childhood wheeze is a major risk factor for asthma. However, not all children who wheeze will develop the disease. The airway epithelium has been shown to be involved in asthma pathogenesis. Despite this, the airway epithelium of children with acute wheeze remains poorly characterized.