A phase I clinical trial assessing the safety, tolerability, and pharmacokinetics of inhaled ethanol in humans as a potential treatment for respiratory tract infections

Current treatments for respiratory infections are severely limited. Ethanol's unique properties including antimicrobial, immunomodulatory, and surfactant-like activity make it a promising candidate treatment for respiratory infections if it can be delivered safely to the airway by inhalation. Here, we explore the safety, tolerability, and pharmacokinetics of inhaled ethanol in a phase I clinical trial.

Citation:
Hansen M, Hart RJ, Milne E, Bower C, Walls ML, et al. Ovulation induction and subfertile untreated conception groups offer improved options for interpreting risks associated with ART. J Assisted Reprod Genet. 2024;41(4):915-928.

Keywords:
ART outcomes; Assisted reproductive technology; IVF; Ovulation induction; Subfertility

Abstract:
To identify and characterise appropriate comparison groups for population studies of health outcomes in ART-conceived births: ovulation induction (OI), subfertile untreated and fertile natural conceptions. Our secondary objective was to examine whether known risks of pregnancy complications and adverse birth outcomes in ART births are elevated in comparison with subfertile (untreated and OI) conception groups.